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Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: A replication study

Ribases, M.; Ramos-Quiroga, J.A.; Sanchez-Mora, C.; Bosch, R.; Richarte, V.; Palomar, G.; Gastaminza, X.; Biesla, A.; Muenke, Maximilian; Arcos-Burgos, Mauricio (Oscar); Castellanos, Francisco Xavier

Description

Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable developmental disorder characterized by a persistent impairing pattern of inattention and/or hyperactivity-impulsivity. Using families from a genetic isolate, the Paisa population from Colombia, and five independent datasets from four different populations (United States, Germany, Norway and Spain), a highly consistent association was recently reported between ADHD and the latrophilin 3 (LPHN3) gene, a...[Show more]

dc.contributor.authorRibases, M.
dc.contributor.authorRamos-Quiroga, J.A.
dc.contributor.authorSanchez-Mora, C.
dc.contributor.authorBosch, R.
dc.contributor.authorRicharte, V.
dc.contributor.authorPalomar, G.
dc.contributor.authorGastaminza, X.
dc.contributor.authorBiesla, A.
dc.contributor.authorMuenke, Maximilian
dc.contributor.authorArcos-Burgos, Mauricio (Oscar)
dc.contributor.authorCastellanos, Francisco Xavier
dc.date.accessioned2015-12-13T22:41:25Z
dc.identifier.issn1601-1848
dc.identifier.urihttp://hdl.handle.net/1885/78498
dc.description.abstractAttention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable developmental disorder characterized by a persistent impairing pattern of inattention and/or hyperactivity-impulsivity. Using families from a genetic isolate, the Paisa population from Colombia, and five independent datasets from four different populations (United States, Germany, Norway and Spain), a highly consistent association was recently reported between ADHD and the latrophilin 3 (LPHN3) gene, a brain-specific member of the LPHN subfamily of G-protein-coupled receptors that is expressed in ADHD-related regions, such as amygdala, caudate nucleus, cerebellum and cerebral cortex. To replicate the association between LPHN3 and ADHD in adults, we undertook a case-control association study in 334 adult patients with ADHD and 334 controls with 43 single nucleotide polymorphisms (SNPs) covering the LPNH3 gene. Single- and multiple-marker analyses showed additional evidence of association between LPHN3 and combined type ADHD in adulthood [P = 0.0019; df = 1; odds ratio (OR) = 1.82 (1.25-2.70) and P = 5.1e-05; df = 1; OR = 2.25 (1.52-3.34), respectively]. These results further support the LPHN3 contribution to combined type ADHD, and specifically to the persistent form of the disorder, and point at this new neuronal pathway as a common susceptibility factor for ADHD throughout the lifespan.
dc.publisherWiley-Blackwell
dc.sourceGenes, Brain and Behavior
dc.subjectKeywords: G protein coupled receptor; latrophilin 3; unclassified drug; adult; amygdaloid nucleus; article; attention deficit disorder; brain cortex; case control study; caudate nucleus; cerebellum; Colombia; controlled study; developmental disorder; female; gene i Adult ADHD; Attention-deficit/hyperactivity disorder; Case-control association study; LPHN3
dc.titleContribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: A replication study
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume10
dc.date.issued2011
local.identifier.absfor060408 - Genomics
local.identifier.absfor060410 - Neurogenetics
local.identifier.absfor060409 - Molecular Evolution
local.identifier.ariespublicationf5625xPUB7133
local.type.statusPublished Version
local.contributor.affiliationRibases, M., Department of Psychiatry,Hospital Universitari Vall d’Hebron, Passeig Vall d’Hebron
local.contributor.affiliationRamos-Quiroga, J.A., Universitat Auto`noma de Barcelona
local.contributor.affiliationSanchez-Mora, C., Department of Psychiatry,Passeig Vall d’Hebron 119-129,08003
local.contributor.affiliationBosch, R., Hospital Universitari Vall d’Hebron
local.contributor.affiliationRicharte, V., Hospital Universitari Vall d’Hebron
local.contributor.affiliationPalomar, G., Hospital Universitari Vall d’Hebron
local.contributor.affiliationGastaminza, X., Hospital Universitari Vall d’Hebron
local.contributor.affiliationBiesla, A., Hospital Universitari Vall d’Hebron
local.contributor.affiliationMuenke, Maximilian, National Human Genome Research Institute
local.contributor.affiliationArcos-Burgos, Mauricio (Oscar), College of Medicine, Biology and Environment, ANU
local.contributor.affiliationCastellanos, Francisco Xavier, New York University
local.description.embargo2037-12-31
local.bibliographicCitation.issue2
local.bibliographicCitation.startpage149
local.bibliographicCitation.lastpage157
local.identifier.doi10.1111/j.1601-183X.2010.00649.x
dc.date.updated2016-02-24T09:33:08Z
local.identifier.scopusID2-s2.0-79951785008
CollectionsANU Research Publications

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