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The Role of Inhibition in Enzyme Evolution

Yu McLoughlin, Sean; Ollis, David

Description

Most people believe that new enzymes evolve from existing enzymes because of the conservation of amino acid sequence and tertiary structures in enzymes with different functions and the low probability that such similarities could evolve independently. However, the process by which this divergence occurs is still debatable. A reasonable proposal for this process is the duplication of a gene encoding an existing enzyme, accumulation of mutations in the gene duplicate(s) with consequential...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/78389
Source: Chemistry and Biology
DOI: 10.1016/j.chembiol.2004.03.031

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