The Unusual Bifunctional Catalysis of Epimerization and Desaturation by Carbapenem Synthase
High-level ab initio calculations have been used to study the mechanism for the conversion of (3S,5S)-carbapenam to the biologically active β-lactam antibiotic, (5R)-carbapenem, catalyzed by carbapenem synthase. This process involves epimerization at C5
|Collections||ANU Research Publications|
|Source:||Journal of the American Chemical Society|
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