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The Unusual Bifunctional Catalysis of Epimerization and Desaturation by Carbapenem Synthase

Topf, Maya; Sandala, Gregory; Smith, David; Schofield, Christopher; Easton, Christopher; Radom, Leo


High-level ab initio calculations have been used to study the mechanism for the conversion of (3S,5S)-carbapenam to the biologically active β-lactam antibiotic, (5R)-carbapenem, catalyzed by carbapenem synthase. This process involves epimerization at C5

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of the American Chemical Society
DOI: 10.1021/ja047899v


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