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Role of T cell costimulation in anti-viral immunity

Bertram, Edward; Dawicki, Wojcieck; Watts, Tania H.


Members of both the CD28 and TNFR families can have costimulatory roles in T cell activation. Gene targeted mice as well as in vivo blocking experiments have established distinct roles for CD28/B7; ICOS/ICOSL; CD27/CD70; 4-1BB/4-1BBL and OX40/OX40L during viral infection. Many issues remain to be addressed, including the timing and location of the interactions, the possibility of partial redundancy between related family members and the molecular basis for the specific phenotypes observed in...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Seminars in Immunology
DOI: 10.1016/j.smim.2004.02.006


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