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Genesis of the strand-biased signature in somatic hypermutation of rearranged immunoglobulin variable genes

Steele, Edward J; Franklin, Andrew; Blanden, Robert


The history and current development of the reverse transcriptase model of somatic hypermutation (RT-model) is reviewed with particular reference to the genesis of strand-biased mutation signatures in rearranged immunoglobulin variable genes (V(D)J). The recent disagreement in the field as to whether strand bias really exists or not has been critically analysed and the confusion traced to the putative presence, in some mutated V(D)J sequence collections, of polymerase chain reaction...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Immunology and Cell Biology
DOI: 10.1046/j.0818-9641.2004.01224.x


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