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Cytotoxicity and DNA binding property of phenanthrene imidazole with polyglycol side chains

Wang, Shuxiang; Li, Hongdong; Chen, Chao; Zhang, Jinchao; Li, Shenghui; Qin, Xinying; Li, Xiaoliu; Wang, Kerang

Description

A series of phenanthrene imidazole with polyglycol side chain (2a-2c and 3a-3c) were synthesized and characterized by IR, NMR and MS. The cytotoxicity of 2a-2c and 3a-3c against cancer cell lines (HL-60, BGC-823, Bel-7402 and KB) in vitro were measured using MTT method. The DNA binding properties of 3a-3c were investigated by UV, fluorescence, CD spectroscopies and thermal denaturation. The results indicate that 2a exhibits higher cytotoxicity than cisplatin against BGC-823 and Bel-7402 cell...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/78281
Source: Bioorganic and Medicinal Chemistry Letters
DOI: 10.1016/j.bmcl.2012.08.079

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