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Activation of protein kinase C inhibits retrograde transport of neurotrophins in mice

Ozsarac, Nesrin; Weible, Michael; Reynolds, Anna; Hendry, Ian


Retrograde axonal transport of neurotrophins from nerve terminal to cell body requires a number of key processes, including internalization of the receptor-neurotrophin complex into vesicles and formation of multivesicular bodies and their transport along the axon. Previous studies have shown that each of these processes can be regulated by kinases. In this study, we looked at the role of protein kinase C (PKC) in retrograde transport by injecting labeled neurotrophins together with relevant...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Neuroscience Research
DOI: 10.1002/jnr.10568


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