Activation of protein kinase C inhibits retrograde transport of neurotrophins in mice
Retrograde axonal transport of neurotrophins from nerve terminal to cell body requires a number of key processes, including internalization of the receptor-neurotrophin complex into vesicles and formation of multivesicular bodies and their transport along the axon. Previous studies have shown that each of these processes can be regulated by kinases. In this study, we looked at the role of protein kinase C (PKC) in retrograde transport by injecting labeled neurotrophins together with relevant...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Neuroscience Research|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.