Perforin and Fas act together in the inductin of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection
In this report we questioned the current view that the two principal cytotoxic pathways, the exocytosis and the Fas ligand (FasL)/Fas-mediated pathway, have largely nonoverlapping biological roles. For this purpose we have analyzed the response of mice that lack Fas as well as granzyme A (gzmA) and gzmB (FasxgzmAxB-/-) to infection with lymphocytic choriomeningitis virus (LCMV). We show that FasxgzmAxB-/- mice, in contrast to B6, Fas-/-, and gzmAxB-/- mice, do not recover from a primary...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Virology|
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