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Perforin and Fas act together in the inductin of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection

Rode, Miriam; Balkow, Sandra; Sobek, Vera; Brehm, R; Martin, Praxedis; Kersten, A; Dumrese, Tilman; Stehle, Thomas; Mullbacher, Arno; Wallich, Reinhard; Simon, Markus M


In this report we questioned the current view that the two principal cytotoxic pathways, the exocytosis and the Fas ligand (FasL)/Fas-mediated pathway, have largely nonoverlapping biological roles. For this purpose we have analyzed the response of mice that lack Fas as well as granzyme A (gzmA) and gzmB (FasxgzmAxB-/-) to infection with lymphocytic choriomeningitis virus (LCMV). We show that FasxgzmAxB-/- mice, in contrast to B6, Fas-/-, and gzmAxB-/- mice, do not recover from a primary...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of Virology
DOI: 10.1128/JVI.78.22.12395-12405.2004


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