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Gene dosage-limiting role of aire in thymic expression, clonal deletion, and organ-specific autoimmunity

Liston, Adrian; Fletcher, Astrid; Gray, Derek; Lesage, Sylvie; Wilson, Judith; Webster, Kylie; Scott, Hamish; Boyd, Richard L; Peltonen, L; Goodnow, Christopher

Description

Inactivation of the autoimmune regulator (Aire) gene causes a rare recessive disorder, autoimmune polyendocrine syndrome 1 (APS1), but it is not known if Aire-dependent tolerance mechanisms are susceptible to the quantitative genetic changes thought to underlie more common autoimmune diseases. In mice with a targeted mutation, complete loss of Aire abolished expression of an insulin promoter transgene in thymic epithelium, but had no effect in pancreatic islets or the testes. Loss of one copy...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/78187
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20040581

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