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Cystinuria-specific rBAT(R365W) mutation reveals two translocation pathways in the amino acid transporter rBAT-b 0,+ AT

Pineda, Marta; Wagner, Carsten; Broer, Angelika; Stehberger, Paul; Kaltenbach, Simone; Gaskett, Chris; Martin del Rio, Rafael; Zorzano, Antonio; Palacin, Manuel; Lang, Florian; Broer, Stefan

Description

Apical reabsorption of dibasic amino acids and cystine in kidney is mediated by the heteromeric amino acid antiporter rBAT/b0,+AT (system b0,+). Mutations in rBAT cause cystinuria type A, whereas mutations in b0,+AT cause cystinuria type B. b0,+AT is the

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/78147
Source: Biochemical Journal

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