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Conduction Mechanisms of Chloride Ions in CIC-Type Channels

Corry, Ben; O'Mara, Megan; Chung, Shin-Ho


The conduction properties of ClC-0 and ClC-1 chloride channels are examined using electrostatic calculations and three-dimensional Brownian dynamics simulations. We create an open-state configuration of the prokaryotic ClC Cl- channel using its known crystallographic structure as a basis. Two residues that are occluding the channel are slowly pushed outward with molecular dynamics to create a continuous ion-conducting path with the minimum radius of 2.5 Å. Then, retaining the same pore shape,...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Biophysical Journal


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