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Specific Ion Effects: Role of Salt and Buffer in Protonation of Cytochrome c

Bostrom, Mathias Anders; Williams, David; Ninham, Barry


Changes in background salt and buffer are known to influence the properties of proteins. The reasons have remained obscure. The challenge posed by many such problems is this. Can physical chemistry contribute any predictive quantitative insights to what is in effect the simplest macromolecular solution behavior? Or must all remain specific? Our thesis is that it can. For definiteness we consider here as an illustrative example: surface pH and protonation equilibria of cytochrome c. We...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: European Physical Journal E
DOI: 10.1140/epje/i2003-10072-0


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