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Choline uptake into the malaria parasite is engergized by the membrane potential

Lehane, Adele; Saliba, Kevin; Allen, Richard; Kirk, Kiaran


The uptake by the intraerythrocytic malaria parasite of the phospholipid precursor choline was investigated in parasites 'isolated' from their host cells by saponin permeabilization of the erythrocyte membrane. Choline is transported across the parasite plasma membrane then phosphorylated and thereby trapped within the parasite. Choline influx was inhibited competitively by quinine. It increased with increasing extracellular pH, decreased on depolarization of the parasite plasma membrane with a...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Biochemical and Biophysical Research Communications
DOI: 10.1016/j.bbrc.2004.05.164


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