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The Malaria Parasites Chloroquine Resistance Transporter is a Member of the Drug/Metabolite Transporter Superfamily

Martin, Rowena; Kirk, Kiaran


The malaria parasite's chloroquine resistance transporter (CRT) is an integral membrane protein localized to the parasite's acidic digestive vacuole. The function of CRT is not known and the protein was originally described as a transporter simply because it possesses 10 transmembrane domains. In wild-type (chloroquine-sensitive) parasites, chloroquine accumulates to high concentrations within the digestive vacuole and it is through interactions in this compartment that it exerts its...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Molecular Biology and Evolution
DOI: 10.1093/molbev/msh205


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