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Phosphomannopentaose Sulfate (PI-88): Heparan Sulfate Mimetic with clinical potential in multiple vascular pathologies

Khachigian, Levon M; Parish, Christopher


The sulfated oligosaccharide PI-88 is a potent antiangiogenic, antitumor and anti-metastatic agent derived from yeast. It is primarily composed of sulfated phosphomannopentaose and phosphomannotetraose oligosaccharide units and is presently under evaluation in Phase II clinical trials for anticancer efficacy. PI-88 inhibits the heparan sulfate-degrading enzyme heparanase, exhibits antiangiogenic activity and has anticoagulant properties mediated by heparin cofactor II. It also inhibits vascular...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Cardiovascular Drug Reviews


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