Phosphomannopentaose Sulfate (PI-88): Heparan Sulfate Mimetic with clinical potential in multiple vascular pathologies
The sulfated oligosaccharide PI-88 is a potent antiangiogenic, antitumor and anti-metastatic agent derived from yeast. It is primarily composed of sulfated phosphomannopentaose and phosphomannotetraose oligosaccharide units and is presently under evaluation in Phase II clinical trials for anticancer efficacy. PI-88 inhibits the heparan sulfate-degrading enzyme heparanase, exhibits antiangiogenic activity and has anticoagulant properties mediated by heparin cofactor II. It also inhibits vascular...[Show more]
|Collections||ANU Research Publications|
|Source:||Cardiovascular Drug Reviews|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.