Inhibition of Protein Interactions with the β 2 Sliding Clamp of Escherichia coli DNA Polymerase III by Peptides from β 2 -Binding Proteins
Wijffels, Gene; Dalrymple, Brian Paul; Prosselkov, Pavel; Kongsuwan, Kritaya; Epa, V; Lilley, Penelope; Jergic, Slobodan; Buchardt, Jens; Brown, Susan Elizabeth; Alewood, Paul F; Jennings, Philip; Dixon, Nicholas
The sliding clamp of the Escherichia coli replisome is now understood to interact with many proteins involved in DNA synthesis and repair. A universal interaction motif is proposed to be one mechanism by which those proteins bind the E. coli sliding clamp, a homodimer of the β subunit, at a single site on the dimer. The numerous β2-binding proteins have various versions of the consensus interaction motif, including a related hexameric sequence. To determine if the variants of the motif could...[Show more]
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