Skip navigation
Skip navigation

Chemical and genetic validation of thiamine utilization as an antimalarial drug target

Chan, Xie; Wrenger, Carsten; Stahl, Katharina; Bergmann, Barbel; Winterberg, Markus; Muller, Ingrid B; Saliba, Kevin

Description

Thiamine is metabolized into an essential cofactor for several enzymes. Here we show that oxythiamine, a thiamine analog, inhibits proliferation of the malaria parasite Plasmodium falciparum in vitro via a thiamine-related pathway and significantly reduce

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
URI: http://hdl.handle.net/1885/77818
Source: Nature Communications
DOI: 10.1038/ncomms3060

Download

File Description SizeFormat Image
01_Chan_Chemical_and_genetic_2013.pdf1.14 MBAdobe PDF


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  12 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator