Chemical and genetic validation of thiamine utilization as an antimalarial drug target
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Chan, Xie; Wrenger, Carsten; Stahl, Katharina; Bergmann, Barbel; Winterberg, Markus; Muller, Ingrid B; Saliba, Kevin
Description
Thiamine is metabolized into an essential cofactor for several enzymes. Here we show that oxythiamine, a thiamine analog, inhibits proliferation of the malaria parasite Plasmodium falciparum in vitro via a thiamine-related pathway and significantly reduce
Collections | ANU Research Publications |
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Date published: | 2013 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/77818 |
Source: | Nature Communications |
DOI: | 10.1038/ncomms3060 |
Access Rights: | Open Access |
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File | Description | Size | Format | Image |
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01_Chan_Chemical_and_genetic_2013.pdf | 1.14 MB | Adobe PDF |
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