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Chemical and genetic validation of thiamine utilization as an antimalarial drug target

Chan, Xie; Wrenger, Carsten; Stahl, Katharina; Bergmann, Barbel; Winterberg, Markus; Muller, Ingrid B; Saliba, Kevin


Thiamine is metabolized into an essential cofactor for several enzymes. Here we show that oxythiamine, a thiamine analog, inhibits proliferation of the malaria parasite Plasmodium falciparum in vitro via a thiamine-related pathway and significantly reduce

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: Nature Communications
DOI: 10.1038/ncomms3060


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