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A polytope DNA vaccine elicits multiple effector and memory CTL responses and protects against human papillomavirus 16 E7-expressing tumour

Doan, Tracy; Herd, Karen; Ramshaw, Ian; Thomson, Scott; Tindle, Robert W


Vaccine-induced CD8 T cells directed to tumour-specific antigens are recognised as important components of protective and therapeutic immunity against tumours. Where tumour antigens have pathogenic potential or where immunogenic epitopes are lost from tumours, development of subunit vaccines consisting of multiple individual epitopes is an attractive alternative to immunising with whole tumour antigen. In the present study we investigate the efficacy of two DNA-based multiepitope ('polytope')...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Cancer Immunology, Immunotherapy: other biological response modifications
DOI: 10.1007/s00262-004-0544-6


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