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The multidrug resistance gene mdrla influences resistance to ectromelia virus infection by mechanisms other than conventional immunity

Xu, D; Regner, Matthias; Smith, David; Ruby, Janet; Johnstone, Ricky; Mullbacher, Arno


P-glycoprotein (P-gp), an ATP-dependent membrane pump encoded by mdr, plays, in addition to its ability to efflux toxins, a role in the resistance to pathogens. We employed mdr 1a gene knock out (mdr 1a-/-) mice and ectromelia virus (EV) to elucidate the

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Immunology and Cell Biology
DOI: 10.1111/j.0818-9641.2004.01274.x


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