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Molecular Cloning of Mouse Amino Acid Transport System B 0 , a Neutral Amino Acid Transporter Related to Hartnup Disorder

Broer, Angelika; Klingel, Karen; Kowalczuk, Sonja; Rasko, John Edward; Cavanaugh, Juleen; Broer, Stefan


Resorption of amino acids in kidney and intestine is mediated by transporters, which prefer groups of amino acids with similar physico-chemical properties. It is generally assumed that most neutral amino acids are transported across the apical membrane of epithelial cells by system B 0. Here we have characterized a novel member of the Na +-dependent neurotransmitter transporter family (B0AT1) isolated from mouse kidney, which shows all properties of system B0. Flux experiments showed that the...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M400904200


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