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Inhibition of Peptidylglycine α-Amidating Monooxygenase by Exploitation of Factors Affecting the Stability and Ease of Formation of Glycyl Radicals

Barratt, Brendon; Easton, Christopher; Henry, David; Li, Iris; Radom, Leo; Simpson, Jamie S


Peptidylglycine α-amidating monooxygenase catalyzes the biosynthesis of peptide hormones through radical cleavage of the C-terminal glycine residues of the corresponding prohormones. We have correlated ab initio calculations of radical stabilization ener

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of the American Chemical Society
DOI: 10.1021/ja046204n


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