Inhibition of Peptidylglycine α-Amidating Monooxygenase by Exploitation of Factors Affecting the Stability and Ease of Formation of Glycyl Radicals
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Barratt, Brendon; Easton, Christopher; Henry, David; Li, Iris; Radom, Leo; Simpson, Jamie S
Description
Peptidylglycine α-amidating monooxygenase catalyzes the biosynthesis of peptide hormones through radical cleavage of the C-terminal glycine residues of the corresponding prohormones. We have correlated ab initio calculations of radical stabilization ener
Collections | ANU Research Publications |
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Date published: | 2004 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/77654 |
Source: | Journal of the American Chemical Society |
DOI: | 10.1021/ja046204n |
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