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Shigella flexneri infection: pathogenesis and vaccine development

Jennison, Amy; Verma, Naresh


Shigella flexneri is a gram-negative bacterium which causes the most communicable of bacterial dysenteries, shigellosis. Shigellosis causes 1.1 million deaths and over 164 million cases each year, with the majority of cases occurring in the children of developing nations. The pathogenesis of S. flexneri is based on the bacteria's ability to invade and replicate within the colonic epithelium, which results in severe inflammation and epithelial destruction. The molecular mechanisms used by S....[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: FEMS Microbiology Reviews
DOI: 10.1016/j.femsre.2003.07.002


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