Measuring environmental factors can enhance the search for disease causing genes?
-
Altmetric Citations
Dwyer, Terence; Ponsonby, Anne-Louise; Stankovich, James; Blizzard, Leigh; Easteal, Simon
Description
The value of the concurrent measurement of environmental factors in studies aimed at the discovery of disease causing genes has been questioned on the grounds that such an approach fails to increase study power. This report discusses the issue and shows with examples from the recent literature that the examination of a gene disease association within an environmental subgroup can provide enhanced opportunities for detecting gene effects. The concurrent collection of environmental as well as...[Show more]
dc.contributor.author | Dwyer, Terence | |
---|---|---|
dc.contributor.author | Ponsonby, Anne-Louise | |
dc.contributor.author | Stankovich, James | |
dc.contributor.author | Blizzard, Leigh | |
dc.contributor.author | Easteal, Simon | |
dc.date.accessioned | 2015-12-13T22:38:18Z | |
dc.date.available | 2015-12-13T22:38:18Z | |
dc.identifier.issn | 0143-005X | |
dc.identifier.uri | http://hdl.handle.net/1885/77496 | |
dc.description.abstract | The value of the concurrent measurement of environmental factors in studies aimed at the discovery of disease causing genes has been questioned on the grounds that such an approach fails to increase study power. This report discusses the issue and shows with examples from the recent literature that the examination of a gene disease association within an environmental subgroup can provide enhanced opportunities for detecting gene effects. The concurrent collection of environmental as well as genetic factors in studies of disease aetiology may enhance study informativeness and validity in several ways, including an increase in the power of the study to detect gene disease associations. | |
dc.publisher | British Medical Association | |
dc.source | Journal of Epidemiology and Community Health | |
dc.subject | Keywords: alcohol dehydrogenase; amine oxidase (flavin containing) isoenzyme A; beta 2 adrenergic receptor; cytochrome P450 1A1; glutathione transferase; pesticide; genetics; aggression; alcohol consumption; antisocial behavior; article; cigarette smoking; DNA poly | |
dc.title | Measuring environmental factors can enhance the search for disease causing genes? | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.description.refereed | Yes | |
local.identifier.citationvolume | 58 | |
dc.date.issued | 2004 | |
local.identifier.absfor | 111706 - Epidemiology | |
local.identifier.ariespublication | MigratedxPub6346 | |
local.type.status | Published Version | |
local.contributor.affiliation | Dwyer, Terence , University of Tasmania | |
local.contributor.affiliation | Ponsonby, Anne-Louise, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Stankovich, James, University of Tasmania | |
local.contributor.affiliation | Blizzard, Leigh, University of Tasmania | |
local.contributor.affiliation | Easteal, Simon, College of Medicine, Biology and Environment, ANU | |
local.bibliographicCitation.startpage | 613 | |
local.bibliographicCitation.lastpage | 615 | |
local.identifier.doi | 10.1136/jech.2003.012971 | |
dc.date.updated | 2015-12-11T09:42:46Z | |
local.identifier.scopusID | 2-s2.0-3042625937 | |
Collections | ANU Research Publications |
Download
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator