The emerging role of pharmacogenetics: implications for clinical psychiatry
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Ng, Chee Hong; Schweitzer, Issac; Norman, Trevor; Easteal, Simon
Description
Objective: This article aims to review the implications of pharmacogenetics for clinical psychiatry; these are discussed in the context of environmental and sociocultural factors. Method: A selective literature review was conducted using Medline search and other relevant references available to the authors. Results: The individual differences in therapeutic and adverse effects of psychotropic drugs are largely determined by genetic factors. Recent advances in pharmacogenetics have highlighted...[Show more]
dc.contributor.author | Ng, Chee Hong | |
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dc.contributor.author | Schweitzer, Issac | |
dc.contributor.author | Norman, Trevor | |
dc.contributor.author | Easteal, Simon | |
dc.date.accessioned | 2015-12-13T22:38:18Z | |
dc.date.available | 2015-12-13T22:38:18Z | |
dc.identifier.issn | 0004-8674 | |
dc.identifier.uri | http://hdl.handle.net/1885/77495 | |
dc.description.abstract | Objective: This article aims to review the implications of pharmacogenetics for clinical psychiatry; these are discussed in the context of environmental and sociocultural factors. Method: A selective literature review was conducted using Medline search and other relevant references available to the authors. Results: The individual differences in therapeutic and adverse effects of psychotropic drugs are largely determined by genetic factors. Recent advances in pharmacogenetics have highlighted the potential utility in predicting metabolic phenotypes, risks for side-effects and likelihood of drug response for the individual patient. Conclusions: Genotyping, especially for drug metabolizing enzymes, could enable more rational, cost-effective and optimal prescribing in future psychopharmacotherapy. Although the advances of pharmacogenetics may have many benefits in clinical practice, the importance of non-genetic factors must also be considered as cultural and environmental factors significantly impinge on response to medications. To clarify the extent pharmacogenetics can be adopted in clinical practice to predict drug response in patients from diverse backgrounds, further studies in different ethnic groups and clinical settings are required. | |
dc.publisher | SAGE Publications | |
dc.source | Australian and New Zealand Journal of Psychiatry | |
dc.subject | Keywords: 10 hydroxynortriptyline; Chinese drug; clozapine; cytochrome P450 1A2; cytochrome P450 2C19; cytochrome P450 2D6; cytochrome P450 3A4; DNA; dopamine transporter; drug metabolizing enzyme; fluoxetine; fluvoxamine; herbaceous agent; Hypericum perforatum ext Drug response; Genotyping; Pharmacogenomics; Psychopharmacology | |
dc.title | The emerging role of pharmacogenetics: implications for clinical psychiatry | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.description.refereed | Yes | |
local.identifier.citationvolume | 38 | |
dc.date.issued | 2004 | |
local.identifier.absfor | 111706 - Epidemiology | |
local.identifier.ariespublication | MigratedxPub6345 | |
local.type.status | Published Version | |
local.contributor.affiliation | Ng, Chee Hong, University of Melbourne | |
local.contributor.affiliation | Schweitzer, Issac, University of Melbourne | |
local.contributor.affiliation | Norman, Trevor, University of Melbourne | |
local.contributor.affiliation | Easteal, Simon, College of Medicine, Biology and Environment, ANU | |
local.bibliographicCitation.issue | 7 | |
local.bibliographicCitation.startpage | 483 | |
local.bibliographicCitation.lastpage | 489 | |
local.identifier.doi | 10.1111/j.1440-1614.2004.01400.x | |
dc.date.updated | 2015-12-11T09:42:46Z | |
local.identifier.scopusID | 2-s2.0-4344648933 | |
Collections | ANU Research Publications |
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