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The emerging role of pharmacogenetics: implications for clinical psychiatry

Ng, Chee Hong; Schweitzer, Issac; Norman, Trevor; Easteal, Simon

Description

Objective: This article aims to review the implications of pharmacogenetics for clinical psychiatry; these are discussed in the context of environmental and sociocultural factors. Method: A selective literature review was conducted using Medline search and other relevant references available to the authors. Results: The individual differences in therapeutic and adverse effects of psychotropic drugs are largely determined by genetic factors. Recent advances in pharmacogenetics have highlighted...[Show more]

dc.contributor.authorNg, Chee Hong
dc.contributor.authorSchweitzer, Issac
dc.contributor.authorNorman, Trevor
dc.contributor.authorEasteal, Simon
dc.date.accessioned2015-12-13T22:38:18Z
dc.date.available2015-12-13T22:38:18Z
dc.identifier.issn0004-8674
dc.identifier.urihttp://hdl.handle.net/1885/77495
dc.description.abstractObjective: This article aims to review the implications of pharmacogenetics for clinical psychiatry; these are discussed in the context of environmental and sociocultural factors. Method: A selective literature review was conducted using Medline search and other relevant references available to the authors. Results: The individual differences in therapeutic and adverse effects of psychotropic drugs are largely determined by genetic factors. Recent advances in pharmacogenetics have highlighted the potential utility in predicting metabolic phenotypes, risks for side-effects and likelihood of drug response for the individual patient. Conclusions: Genotyping, especially for drug metabolizing enzymes, could enable more rational, cost-effective and optimal prescribing in future psychopharmacotherapy. Although the advances of pharmacogenetics may have many benefits in clinical practice, the importance of non-genetic factors must also be considered as cultural and environmental factors significantly impinge on response to medications. To clarify the extent pharmacogenetics can be adopted in clinical practice to predict drug response in patients from diverse backgrounds, further studies in different ethnic groups and clinical settings are required.
dc.publisherSAGE Publications
dc.sourceAustralian and New Zealand Journal of Psychiatry
dc.subjectKeywords: 10 hydroxynortriptyline; Chinese drug; clozapine; cytochrome P450 1A2; cytochrome P450 2C19; cytochrome P450 2D6; cytochrome P450 3A4; DNA; dopamine transporter; drug metabolizing enzyme; fluoxetine; fluvoxamine; herbaceous agent; Hypericum perforatum ext Drug response; Genotyping; Pharmacogenomics; Psychopharmacology
dc.titleThe emerging role of pharmacogenetics: implications for clinical psychiatry
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume38
dc.date.issued2004
local.identifier.absfor111706 - Epidemiology
local.identifier.ariespublicationMigratedxPub6345
local.type.statusPublished Version
local.contributor.affiliationNg, Chee Hong, University of Melbourne
local.contributor.affiliationSchweitzer, Issac, University of Melbourne
local.contributor.affiliationNorman, Trevor, University of Melbourne
local.contributor.affiliationEasteal, Simon, College of Medicine, Biology and Environment, ANU
local.bibliographicCitation.issue7
local.bibliographicCitation.startpage483
local.bibliographicCitation.lastpage489
local.identifier.doi10.1111/j.1440-1614.2004.01400.x
dc.date.updated2015-12-11T09:42:46Z
local.identifier.scopusID2-s2.0-4344648933
CollectionsANU Research Publications

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