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Induction of therapeutic T-cell responses to subdominant tumor-associated viral oncogene after immunization with replication-incompetent polyepitope adenovirus vaccine

Duraiswamy, Jai; Bharadwaj, M; Tellam, Judy; Connolly, Geoff; Cooper, Leanne; Moss, Denis J; Thomson, Scott; Yotnda, P; Khanna, Rajiv


The EBV-encoded latent membrane proteins (LMP1 and LMP2), which are expressed in various EBV-associated malignancies have been proposed as a potential target for CTL-based therapy. However, the precursor frequency for LMP-specific CTL is generally low, and immunotherapy based on these antigens is often compromised by the poor immunogenicity and potential threat from their oncogenic potential. Here we have developed a replication-incompetent adenoviral vaccine that encodes multiple HLA class...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Cancer Research
DOI: 10.1158/0008-5472.CAN-03-2196


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