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Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis

Pardo, Julian; Bosque, Alberto; Brehm, R; Wallich, Reinhard; Naval, Javier; Mullbacher, Arno; Anel, A; Simon, Markus M


Purified cytolytic T lymphocyte (CTL) proteases granzyme (gzm)A and gzmB with sublytic dose of perforin (perf) initiate distinct proapoptotic pathways. Their physiological relevance in CTL-mediated target cell apoptosis is elusive. Using ex vivo virus-immune CD8+ T cells from mice deficient in perf, gzmA and/or gzmB, and the Fas-resistant EL4.F15 tumor target cell, we show that (a) CTL from gzmA-/- or gzmB-/- mice similarly induced early proapoptotic features, such as phosphatidyl serine (PS)...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of Cell Biology
DOI: 10.1083/jcb.200406115


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