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An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development

Lee, Jeffrey D; Krause, Petra; Gaiano, Nicholas; Vaz da Silva de Castro Nery, Susana; Kohtz, Jhumku; Fishell, Gord; Loomis, Cynthia A; Treisman, Jessica E

Description

The Drosophila Hedgehog protein and its vertebrate counterpart Sonic hedgehog are required for a wide variety of patterning events throughout development. Hedgehog proteins are secreted from cells and undergo autocatalytic cleavage and cholesterol modification to produce a mature signaling domain. This domain of Sonic hedgehog has recently been shown to acquire an N-terminal acyl group in cell culture. We have investigated the in vivo role that such acylation might play in appendage patterning...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
URI: http://hdl.handle.net/1885/77338
Source: Developmental Biology
DOI: 10.1006/dbio.2001.0218

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