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Tolerance induction by molecular mimicry: prevention and supression of experimental autoimmune encephalomyelitis with the milk protein butyrophilin

Mana, Paula; Goodyear, Melinda; Bernard, Claude; Tomioka, Ryo; Freire-Garabal, Manuel; Linares, David


Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system. Although the etiology of MS remains unknown, studies in experimental autoimmune encephalomyelitis (EAE) have suggested that foreign molecules, which show molecular mimicry with myelin antigens, may play an important role as causative agents of the human disease. In this study, we investigate the molecular mimicry between the extracellular Ig-like domain of the cow's milk protein butyrophilin (BTN) and the...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: International Immunology
DOI: 10.1093/intimm/dxh049


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