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Acute Human Self-Poisoning with the N-Phenylpyrazole Insecticide Fipronil - a GABA(A) - Gated Chloride Channel Blocker

Mohammed, Fahim; Senarathna, Lalith; Percy, Adrian; Abeyewardene, Manel; Eaglesham, Geoffrey; Cheng, Ron; Azhar, Shifa; Hittarage, Ariyasena; Di Stasio, Robert; Sheriff, M H Rezvi; Davies, Willie; Buckley, Nicholas; Eddleston, Michael

Description

Objective: Fipronil, a broad spectrum N-phenylpyrazole insecticide that inhibits GABAA-gated chloride channels, has been in use since the mid-199Os. A high affinity for insect compared to mammalian GABA receptors results in lower animal toxicity than other insecticides blocking this channel. To date, only two accidental cases of fipronil poisoning in humans have been published. Case Series: We report seven patients with fipronil self-poisoning seen prospectively in Sri Lanka together with...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/77260
Source: Clinical Toxicology (Taylor & Francis)
DOI: 10.1081/CLT-200041784

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