Acute Human Self-Poisoning with the N-Phenylpyrazole Insecticide Fipronil - a GABA(A) - Gated Chloride Channel Blocker
Mohammed, Fahim; Senarathna, Lalith; Percy, Adrian; Abeyewardene, Manel; Eaglesham, Geoffrey; Cheng, Ron; Azhar, Shifa; Hittarage, Ariyasena; Di Stasio, Robert; Sheriff, M H Rezvi; Davies, Willie; Buckley, Nicholas; Eddleston, Michael
Objective: Fipronil, a broad spectrum N-phenylpyrazole insecticide that inhibits GABAA-gated chloride channels, has been in use since the mid-199Os. A high affinity for insect compared to mammalian GABA receptors results in lower animal toxicity than other insecticides blocking this channel. To date, only two accidental cases of fipronil poisoning in humans have been published. Case Series: We report seven patients with fipronil self-poisoning seen prospectively in Sri Lanka together with...[Show more]
|Collections||ANU Research Publications|
|Source:||Clinical Toxicology (Taylor & Francis)|
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