What is the importance of multivesicular bodies in retrograde axonal transport in vivo?
Neurons with long axons have a unique problem in generating signaling cascades that are able to reach the nucleus after receptor activation by neurotrophins at the nerve terminal. The straightforward concept of receptor binding and local generation of 2nd second messenger cascades is too simplistic. In this review we will outline a mechanism that would enable the complex signals generated at the nerve terminal to be conveyed intact to the cell body. There are three different sites in the neuron...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Neurobiology|