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Carbon Monoxide Disposition and Permeability-Surface Area Product in the Foetal Circulation of the Perfused Term Human Placenta

Sangalli, M; McLean, Allan; Peek, M; Rivory, L.; Le Couteur, D

Description

In order to estimate the placental barrier to gas transfer, a novel carbon monoxide (CO) wash-in method was used to estimate the permeability-surface area (PS) product for the transfer of gas across the foetal circulation in the perfused human term placenta. The PS product for CO was 0.0096 ± 0.006 ml/s/g or 0.012 ± 0.007 ml/s/g using compartmental or Crone-Renkin analysis, respectively. Using this result and a published estimate of the placental capillary surface area, the permeability...[Show more]

dc.contributor.authorSangalli, M
dc.contributor.authorMcLean, Allan
dc.contributor.authorPeek, M
dc.contributor.authorRivory, L.
dc.contributor.authorLe Couteur, D
dc.date.accessioned2015-12-13T22:37:47Z
dc.identifier.issn0143-4004
dc.identifier.urihttp://hdl.handle.net/1885/77246
dc.description.abstractIn order to estimate the placental barrier to gas transfer, a novel carbon monoxide (CO) wash-in method was used to estimate the permeability-surface area (PS) product for the transfer of gas across the foetal circulation in the perfused human term placenta. The PS product for CO was 0.0096 ± 0.006 ml/s/g or 0.012 ± 0.007 ml/s/g using compartmental or Crone-Renkin analysis, respectively. Using this result and a published estimate of the placental capillary surface area, the permeability coefficient to CO across the foetal circulation was found to be approximately 4 × 10-5 cm/s. This result is compatible with the hypothesis that the foetal circulation of the human placenta imposes a potentially significant barrier to gas transfer.
dc.publisherW B Saunders Co
dc.sourcePlacenta
dc.subjectKeywords: carbon monoxide; oxygen; article; blood placenta barrier; capillary permeability; compartment model; controlled study; female; fetus circulation; gas diffusion; human; human tissue; hypothesis; oxygen transport; permeability; placenta circulation; placent
dc.titleCarbon Monoxide Disposition and Permeability-Surface Area Product in the Foetal Circulation of the Perfused Term Human Placenta
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume24
dc.date.issued2003
local.identifier.absfor111404 - Reproduction
local.identifier.ariespublicationMigratedxPub6144
local.type.statusPublished Version
local.contributor.affiliationSangalli, M, Canberra Hospital
local.contributor.affiliationMcLean, Allan, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationPeek, M, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationRivory, L., University of Sydney
local.contributor.affiliationLe Couteur, D, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage8
local.bibliographicCitation.lastpage11
local.identifier.doi10.1053/plac.2002.0877
dc.date.updated2015-12-11T09:38:32Z
local.identifier.scopusID2-s2.0-0141503463
CollectionsANU Research Publications

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