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Carbon Monoxide Disposition and Permeability-Surface Area Product in the Foetal Circulation of the Perfused Term Human Placenta

Sangalli, M; McLean, Allan; Peek, M; Rivory, L.; Le Couteur, D


In order to estimate the placental barrier to gas transfer, a novel carbon monoxide (CO) wash-in method was used to estimate the permeability-surface area (PS) product for the transfer of gas across the foetal circulation in the perfused human term placenta. The PS product for CO was 0.0096 ± 0.006 ml/s/g or 0.012 ± 0.007 ml/s/g using compartmental or Crone-Renkin analysis, respectively. Using this result and a published estimate of the placental capillary surface area, the permeability...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Placenta
DOI: 10.1053/plac.2002.0877


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