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Exocytosis and Fas mediated cytolytic mechanisms exert protection from West Nile virus induced encephalitis in mice

Wang, Yang; Lobigs, Mario; Lee, Eva; Mullbacher, Arno


Infection of mice with the flaviviruses West Nile virus (WNV) and Murray Valley encephalitis (MVE) induces cytolytic T-cell responses which are highly cross-reactive on target cells infected with heterologous flaviviruses. Of C57BL/6 mice infected with low doses (102-106 PFU) of either virus, 30-40% develop encephalitis and die within 10-12 days. 1,2 Mice with defects in the Fas or granule exocytosis (perforin and granzymes A and B) pathway of cellular cytotoxicity display reduced mortality and...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Immunology and Cell Biology
DOI: 10.1046/j.0818-9641.2004.01227.x


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