Dora, Kim A; Hill, Caryl; Sandow, Shaun L; Gallagher, Nicola T; Takano, Hiromichi; Rummery, Nicole; Garland, Chris J
Endothelium-dependent hyperpolarization of vascular smooth muscle provides a major pathway for relaxation in resistance arteries. This can occur due to direct electrical coupling via myoendothelial gap junctions (MEGJs) and/or the release of factors (EDHF). Here we provide evidence for the existence of functional MEGJs in the same, defined branches of BALB/C mouse mesenteric arteries which show robust EDHF-mediated smooth muscle relaxation. Cyclopiazonic acid (CPA, 10 μM) was used to stimulate...[Show more]
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