Skip navigation
Skip navigation

Myoendothelial gap junctions may provide the pathway for EDHF in mouse mesenteric artery

Dora, Kim A; Hill, Caryl; Sandow, Shaun L; Gallagher, Nicola T; Takano, Hiromichi; Rummery, Nicole; Garland, Chris J

Description

Endothelium-dependent hyperpolarization of vascular smooth muscle provides a major pathway for relaxation in resistance arteries. This can occur due to direct electrical coupling via myoendothelial gap junctions (MEGJs) and/or the release of factors (EDHF). Here we provide evidence for the existence of functional MEGJs in the same, defined branches of BALB/C mouse mesenteric arteries which show robust EDHF-mediated smooth muscle relaxation. Cyclopiazonic acid (CPA, 10 μM) was used to stimulate...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
URI: http://hdl.handle.net/1885/77234
Source: Journal of Vascular Research
DOI: 10.1159/000074549

Download

File Description SizeFormat Image
01_Dora_Myoendothelial_gap_junctions_2003.pdf243.71 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator