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Multiple steps of phosphorylation of activated rhodopsin can account for the reproducibility of vertebrate rod single-photon responses

Hamer, Russell D; Nicholas, S C; Tranchina, D; Liebman, P; Lamb, Trevor

Description

Single-photon responses (SPRs) in vertebrate rods are considerably less variable than expected if isomerized rhodopsin (R*) inactivated in a single, memoryless step, and no other variability-reducing mechanisms were available. We present a new stochastic

dc.contributor.authorHamer, Russell D
dc.contributor.authorNicholas, S C
dc.contributor.authorTranchina, D
dc.contributor.authorLiebman, P
dc.contributor.authorLamb, Trevor
dc.date.accessioned2015-12-13T22:37:45Z
dc.identifier.issn0022-1295
dc.identifier.urihttp://hdl.handle.net/1885/77233
dc.description.abstractSingle-photon responses (SPRs) in vertebrate rods are considerably less variable than expected if isomerized rhodopsin (R*) inactivated in a single, memoryless step, and no other variability-reducing mechanisms were available. We present a new stochastic
dc.publisherRockefeller University Press
dc.sourceJournal of General Physiology
dc.subjectKeywords: rhodopsin; animal cell; animal tissue; article; DNA modification; Monte Carlo method; mouse; nonhuman; phototransduction; protein phosphorylation; retina rod; stochastic model; vertebrate; Adenosine Triphosphate; Animals; Biotransformation; Calcium Signal Multiple phosphorylation; Phototransduction; Rod responses; Single-photon response reproducibility; Stochastic model
dc.titleMultiple steps of phosphorylation of activated rhodopsin can account for the reproducibility of vertebrate rod single-photon responses
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume122
dc.date.issued2003
local.identifier.absfor110906 - Sensory Systems
local.identifier.ariespublicationMigratedxPub6129
local.type.statusPublished Version
local.contributor.affiliationHamer, Russell D, Smith-Kettlewell Eye Institute
local.contributor.affiliationNicholas, S C, Smith-Kettlewell Eye Institute
local.contributor.affiliationTranchina, D, New York University
local.contributor.affiliationLiebman, P, University of Pennsylvania
local.contributor.affiliationLamb, Trevor, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue4
local.bibliographicCitation.startpage419
local.bibliographicCitation.lastpage444
local.identifier.doi10.1085/jgp.200308832
dc.date.updated2015-12-11T09:38:26Z
local.identifier.scopusID2-s2.0-0141919837
CollectionsANU Research Publications

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