Granzymes in cytolytic lymphocytes to kill a killer?
Granzymes (gzm) are major components of the granules of cytolytic lymphocytes, natural killer and cytotoxic T cells. Their generally accepted mode of action consists of their directed secretion towards a virus-infected or neoplastic target cell and perforin-dependent delivery to the target cell cytosol, where they engage in various actions resulting in target cell apoptosis. Here, based on observations of infection of gzmAxB-/- mice with ectromelia virus, mousepox, we propose an additional -...[Show more]
|Collections||ANU Research Publications|
|Source:||Immunology and Cell Biology|