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Granzymes in cytolytic lymphocytes to kill a killer?

Regner, Matthias; Mullbacher, Arno


Granzymes (gzm) are major components of the granules of cytolytic lymphocytes, natural killer and cytotoxic T cells. Their generally accepted mode of action consists of their directed secretion towards a virus-infected or neoplastic target cell and perforin-dependent delivery to the target cell cytosol, where they engage in various actions resulting in target cell apoptosis. Here, based on observations of infection of gzmAxB-/- mice with ectromelia virus, mousepox, we propose an additional -...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Immunology and Cell Biology
DOI: 10.1046/j.0818-9641.2004.01225.x


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