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Polarized type 1 cytokine response and cell-mediated immunity determine genetic resistance to mousepox

Chaudhri, Geeta; Panchanathan, Vijay; Buller, R Mark; van den Eertwegh, Alfons; Claassen, E; Zhou, Jiansheng; De Chazal, Rosalind; Laman, J; Karupiah, Gunasegaran


Ectromelia virus (ECTV), a natural mouse pathogen and an orthopoxvirus, has been used to investigate the correlation between polarized type 1 or type 2 immune responses and resistance to disease in poxvirus infections by using well defined resistant and susceptible mouse strains. Our data show that distinct differences exist in the cytokine profiles expressed in resistant and susceptible mice infected with ECTV. Resistant C57BL/6 mice generate a type 1 cytokine response [IFN-γ, IL-2, and tumor...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.0402949101


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