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Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men

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Lehmann, D; Butler, H T; Warden, D R; Combrink, M; King, E; Nicoll, J; Budge, Marc; de Jager, Celeste A; Hogervorst, E; Esiri, M M; Ragoussis, J.; Smith, J. Allyn

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We examined the CAG repeat polymorphism in exon 1 of the androgen receptor (AR) in an Oxford cohort of 150 cases (101 men) of definite or probable Alzheimer's disease (AD) and 190 elderly controls (140 men). We found that short alleles (≤20 CAG repeats)

dc.contributor.authorLehmann, D
dc.contributor.authorButler, H T
dc.contributor.authorWarden, D R
dc.contributor.authorCombrink, M
dc.contributor.authorKing, E
dc.contributor.authorNicoll, J
dc.contributor.authorBudge, Marc
dc.contributor.authorde Jager, Celeste A
dc.contributor.authorHogervorst, E
dc.contributor.authorEsiri, M M
dc.contributor.authorRagoussis, J.
dc.contributor.authorSmith, J. Allyn
dc.date.accessioned2015-12-13T22:36:58Z
dc.date.available2015-12-13T22:36:58Z
dc.identifier.issn0304-3940
dc.identifier.urihttp://hdl.handle.net/1885/77029
dc.description.abstractWe examined the CAG repeat polymorphism in exon 1 of the androgen receptor (AR) in an Oxford cohort of 150 cases (101 men) of definite or probable Alzheimer's disease (AD) and 190 elderly controls (140 men). We found that short alleles (≤20 CAG repeats)
dc.publisherElsevier
dc.sourceNeuroscience Letters
dc.subjectKeywords: adult; allele; Alzheimer disease; article; cohort analysis; confidence interval; controlled study; disease association; exon; genetic polymorphism; human; major clinical study; male; onset age; priority journal; risk factor; Aged; Aged, 80 and over; Allel Apolipoprotein E e4; Butyrylcholinesterase K variant; Estrogen; Gender; Neuroprotection; Sex steroids; Testosterone; X chromosome
dc.titleAssociation of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume340
dc.date.issued2003
local.identifier.absfor110306 - Endocrinology
local.identifier.ariespublicationMigratedxPub5876
local.type.statusPublished Version
local.contributor.affiliationLehmann, D, Oxford Project to Investigate Memory and Ageing (OPTIMA)
local.contributor.affiliationButler, H T, University of Oxford
local.contributor.affiliationWarden, D R, Oxford University
local.contributor.affiliationCombrink, M, University of Oxford
local.contributor.affiliationKing, E, Oxford Project to Investigate Memory and Ageing (OPTIMA)
local.contributor.affiliationNicoll, J, University of Southampton
local.contributor.affiliationBudge, Marc, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationde Jager, Celeste A, University of Oxford
local.contributor.affiliationHogervorst, E, University of Oxford
local.contributor.affiliationEsiri, M M, University of Oxford
local.contributor.affiliationRagoussis, J., University of Oxford
local.contributor.affiliationSmith, J. Allyn, Los Alamos National Laboratory
local.bibliographicCitation.startpage87
local.bibliographicCitation.lastpage90
local.identifier.doi10.1016/S0304-3940(03)00069-7
dc.date.updated2015-12-11T09:34:27Z
local.identifier.scopusID2-s2.0-0345268657
CollectionsANU Research Publications

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