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Homocysteine as a Risk Factor for Cognitive Impairment in Stroke Patients

Sachdev, Perminder Singh; Valenzuela, Michael; Brodaty, Henry; Wang, Xing; Looi, Jeffrey; Lorentz, Lisa; Howard, Lesley; Jones, Megan; Zagami, Alessandro; Gillies, David; Wilcken, David


Background: Elevated total homocysteine (tHcy) levels are associated with an increased risk of cerebrovascular disease. It is uncertain whether tHcy is also an independent risk factor for cognitive impairment. Methods: We examined 95 stroke subjects 3 months after their strokes, and 55 healthy comparison subjects, with a detailed neuropsychological assessment, and MRI brain scans in a proportion (n = 97). Baseline measurements of tHcy, serum folate and B12, creatinine and plasma fibrinogen...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Dementia and Geriatric Cognitive Disorders
DOI: 10.1159/000068481


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