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Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4R�-independent airway hyperreactivity

Webb, Dianne; Mahalingam, Surendran; Cai, Yeping; Matthaei, Klaus; Donaldson, Debra; Foster, Paul S

Description

The pathogenesis of human asthma and the development of key features of pulmonary allergy in mouse models has been critically linked to IL-13. Analyses of the receptor components employed by IL-13 have shown that delivery of this cytokine to the airways of naive IL-4Rα gene targeted (IL-4Rα-/-) mice fails to induce disease, suggesting that this membrane protein is critical for transducing IL-13-mediated responses. The current study demonstrates that, in contrast to naive mice, T helper 2 bias,...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
URI: http://hdl.handle.net/1885/76910
Source: European Journal of Immunology
DOI: 10.1002/eji.200324178

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