Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4R�-independent airway hyperreactivity
The pathogenesis of human asthma and the development of key features of pulmonary allergy in mouse models has been critically linked to IL-13. Analyses of the receptor components employed by IL-13 have shown that delivery of this cytokine to the airways of naive IL-4Rα gene targeted (IL-4Rα-/-) mice fails to induce disease, suggesting that this membrane protein is critical for transducing IL-13-mediated responses. The current study demonstrates that, in contrast to naive mice, T helper 2 bias,...[Show more]
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|Source:||European Journal of Immunology|
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