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Mechanisms of hypervirulent Clostridium difficile ribotype 027 displacement of endemic strains: An epidemiological model

Yakob, Laith; Riley, Thomas; Paterson, D L; Marquess, John; Magalhaes, Ricardo Soares; Furuya Kanamori, Luis; Clements, Archie


Following rapid, global clonal dominance of hypervirulent ribotypes, Clostridium difficile now constitutes the primary infectious cause of nosocomial diarrhoea. Evidence indicates at least three possible mechanisms of hypervirulence that facilitates the successful invasion of these atypical strains: 1) increased infectiousness relative to endemic strains; 2) increased symptomatic disease rate relative to endemic strains; and 3) an ability to outcompete endemic strains in the host's gut....[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Scientific Reports
DOI: 10.1038/srep12666
Access Rights: Open Access


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