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A Plant-Based Allergy Vaccine Suppresses Experimental Asthma Via an IFN-㠡nd CD4+CD45RBlow T Cell-Dependent Mechanism

Prescott, Vanessa; Foster, Paul S; Rothenberg, Marc E; Higgins, T J V; Hogan, Simon

Description

Allergic asthma is currently considered a chronic airway inflammatory disorder associated with the presence of activated CD4+ Th2-type lymphocytes, eosinophils, and mast cells. Interestingly, therapeutic strategies based on immune deviation and suppression have been shown to successfully attenuate the development of the asthma phenotype. In this investigation, we have for the first time used a genetically modified (GM) plant, narrow leaf lupin (Lupinus angustifolius L.), expressing a gene for a...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
URI: http://hdl.handle.net/1885/76767
Source: Journal of Immunology

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