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Marsupials and monotremes possess a novel family of MHC class I genes that is lost from the eutherian lineage

Papenfuss, Anthony T; Feng, Zhi-Ping; Krasnec, Katina; Deakin, Janine; Baker, Michelle L; Miller, Robert D

Description

Background: Major histocompatibility complex (MHC) class I genes are found in the genomes of all jawed vertebrates. The evolution of this gene family is closely tied to the evolution of the vertebrate genome. Family members are frequently found in four paralogous regions, which were formed in two rounds of genome duplication in the early vertebrates, but in some species class Is have been subject to additional duplication or translocation, creating additional clusters. The gene family is...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/76703
Source: BMC Genomics
DOI: 10.1186/s12864-015-1745-4

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