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Enhanced serotonin response in the hippocampus of Galphaz protein knock-out mice

Oleskevich, Sharon; Leck, Kwong-Joo; Matthaei, Klaus; Hendry, Ian


The serotonin-1A [5-hydroxytryptamine 1A (5HT1A)] receptor is important for emotional and homeostatic processes in the central nervous system. In the hippocampus, the 5HT1A receptor couples to inhibitory Gi/o proteins to decrease pyramidal cell excitability. Here we investigate the 5HT1A receptor in a mouse deficient in the α-subunit of Gz protein (Gαz knock-out). Behavioural tests showed heightened anxiety and depression-like behaviour in the Gαz knock-out mice. Whole-cell recording in CA1...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: NeuroReport
DOI: 10.1097/00001756-200506210-00009


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