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Fluid secretion and the Na+ -K+ -2Cl- cotransporter in mouse exorbital lacrimal gland

Walcott, Benjamin; Birzgalis, Aija; Moore, Leon C; Brink, Peter R


We have previously suggested that fluid flow in the mouse exorbital lacrimal gland is driven by the opening of apical Cl- and K + channels. These ions move into the lumen of the gland and water follows by osmosis. In many tissues, the Na+-K+-2Cl - cotransporter (NKCC1) replaces the Cl- and K+ ions that move into the lumen. We hypothesize that mouse exorbital lacrimal glands would have NKCC1 cotransporters and that they would be important in fluid transport by this gland. We used...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: American Journal of Physiology - Cell Physiology
DOI: 10.1152/ajpcell.00526.2004


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