Skip navigation
Skip navigation

C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties

Banwell, Martin; Bezos, Anna; Burns, Christopher; Kruszelnicki, Irma; Parish, Christopher; Su, Stephen; Sydnes, Magne

Description

Four enantiomerically pure monoseco-analogues, 5, 7, 9, and 11, of the phenanthroquinolizidine alkaloid julandine (1) and four of congener cryptopleurine (2), viz. compounds 6, 8, 10, and 12, have been prepared and subjected to preliminary biological evaluation. These analogues show dramatically reduced cytotoxicity compared with the parent system 2 but they are, nevertheless, potent anti-angiogenic agents.

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/76590
Source: Bioorganic and Medicinal Chemistry Letters
DOI: 10.1016/j.bmcl.2005.09.032

Download

File Description SizeFormat Image
01_Banwell_C8c-C15_monoseco-analogues_of_2006.pdf166 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator