C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties
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Banwell, Martin; Bezos, Anna; Burns, Christopher; Kruszelnicki, Irma; Su, Stephen; Sydnes, Magne; Parish, Christopher
Description
Four enantiomerically pure monoseco-analogues, 5, 7, 9, and 11, of the phenanthroquinolizidine alkaloid julandine (1) and four of congener cryptopleurine (2), viz. compounds 6, 8, 10, and 12, have been prepared and subjected to preliminary biological evaluation. These analogues show dramatically reduced cytotoxicity compared with the parent system 2 but they are, nevertheless, potent anti-angiogenic agents.
Collections | ANU Research Publications |
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Date published: | 2006 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/76590 |
Source: | Bioorganic and Medicinal Chemistry Letters |
DOI: | 10.1016/j.bmcl.2005.09.032 |
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01_Banwell_C8c-C15_monoseco-analogues_of_2006.pdf | 166 kB | Adobe PDF | Request a copy |
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