Skip navigation
Skip navigation

Functional implications of modifying RyR-activating peptides for membrane permeability

Dulhunty, Angela; Cengia, Louise; Young, Jaqui; Pace, Suzy M; Lamb, Graham; Harvey, Peta; Chan, Yao-ban; Wimmer, Norbert; Toth, Istvan; Casarotto, Marco

Description

Our aim was to determine whether lipoamino acid conjugation of peptides that are high-affinity activators of ryanodine receptor (RyR) channels would (a) render the peptides membrane permeable, (b) alter their structure or (a) reduce their activity. The peptides correspond to the A region of the II-III loop of the skeletal dihydropyridine receptor. The lipoamino acid conjugation increased the apparent permeability of the peptide across the Caco-2 cell monolayer by up to ∼20-fold. Nuclear...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/76559
Source: British Journal of Pharmacology
DOI: 10.1038/sj.bjp.0705981

Download

File Description SizeFormat Image
01_Dulhunty_Functional_implications_of_2005.pdf390.73 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator