Functional implications of modifying RyR-activating peptides for membrane permeability
Our aim was to determine whether lipoamino acid conjugation of peptides that are high-affinity activators of ryanodine receptor (RyR) channels would (a) render the peptides membrane permeable, (b) alter their structure or (a) reduce their activity. The peptides correspond to the A region of the II-III loop of the skeletal dihydropyridine receptor. The lipoamino acid conjugation increased the apparent permeability of the peptide across the Caco-2 cell monolayer by up to ∼20-fold. Nuclear...[Show more]
|Collections||ANU Research Publications|
|Source:||British Journal of Pharmacology|
|01_Dulhunty_Functional_implications_of_2005.pdf||390.73 kB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.