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Transgenic Expression of Bean alpha-Amylase Inhibitor in Peas Results in Altered Structure and Immunogenicity

Prescott, Vanessa; Campbell, Peter M; Moore, Andrew; Mattes, Joerg; Rothenberg, Marc E; Foster, Paul S; Higgins, T J V; Hogan, Simon


The development of modern gene technologies allows for the expression of recombinant proteins in non-native hosts. Diversity in translational and post-translational modification pathways between species could potentially lead to discrete changes in the molecular architecture of the expressed protein and subsequent cellular function and antigenicity. Here, we show that transgenic expression of a plant protein (α-amylase inhibitor-1 from the common bean (Phaseolus vulgaris L. cv. Tendergreen)) in...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Journal of Agricultural and Food Chemistry
DOI: 10.1021/jf050594v


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