A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
Garcia De Vinuesa, Maria Carola; Cook, Matthew; Angelucci, C; Athanasopoulos, Vicki; Rui, Lixin; Hill, K; Yu, Di; Domaschenz, Heather; Whittle, Belinda; Lambe, Teresa; Roberts, Ian S; Copley, Richard R; Bell, John I; Cornall, Richard J; Goodnow, Christopher
Despite the sequencing of the human and mouse genomes, few genetic mechanisms for protecting against autoimmune disease are currently known. Here we systematically screen the mouse genome for autoimmune regulators to isolate a mouse strain, sanroque, with severe autoimmune disease resulting from a single recessive defect in a previously unknown mechanism for repressing antibody responses to self. The sonroque mutation acts within mature T cells to cause formation of excessive numbers of...[Show more]
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