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CARD15/NOD2 Risk alleles in the development of Crohn's disease in the Australian population

Cavanaugh, Juleen; Adams, K E; Quak, E J; Bryce, Michaela E; O'Callaghan, N J; Rodgers, Helen J; Magarry, G R; Butler, W J; Eaden, J A; Roberts-Thomson, I; Pavli, Paul; Wilson, Susan; Callen, D F


We have previously reported strong evidence for linkage between IBD1 and Crohn's disease (CD) in Australian Crohn's disease families. Three risk alleles for Crohn's disease, (Arg702 Trp (C/T), GlY908 Arg (G/C) and 980fs 981 (-/C), were recently identified in the CARD15/NOD2 gene on chromosome 16, implicating this as the IBD1 locus. Using a novel diagnostic PCR-RFLP, we have examined the frequency of these alleles in 205 multiplex IBD families, 107 sporadic Crohn's disease cases and 409 normal...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Annals of Human Genetics
DOI: 10.1046/j.1469-1809.2003.00006.x


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