CARD15/NOD2 Risk alleles in the development of Crohn's disease in the Australian population
We have previously reported strong evidence for linkage between IBD1 and Crohn's disease (CD) in Australian Crohn's disease families. Three risk alleles for Crohn's disease, (Arg702 Trp (C/T), GlY908 Arg (G/C) and 980fs 981 (-/C), were recently identified in the CARD15/NOD2 gene on chromosome 16, implicating this as the IBD1 locus. Using a novel diagnostic PCR-RFLP, we have examined the frequency of these alleles in 205 multiplex IBD families, 107 sporadic Crohn's disease cases and 409 normal...[Show more]
|Collections||ANU Research Publications|
|Source:||Annals of Human Genetics|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.